By Robert S. Matson
Microarrays play an more and more major function in drug discovery. the industrial panorama has replaced dramatically during the last few years and researchers have made nice developments with reference to building and use. Now in its moment version, employing Genomic and Proteomic Microarray know-how in Drug Discovery highlights, describes, and evaluates present medical learn utilizing microarray expertise in genomic and proteomic purposes. up-to-date and revised to mirror fresh development within the box, the second one variation discusses: accelerated omics-driven purposes, together with the areas. Read more...
summary: Microarrays play an more and more major function in drug discovery. the economic panorama has replaced dramatically over the last few years and researchers have made nice developments with reference to building and use. Now in its moment variation, utilizing Genomic and Proteomic Microarray know-how in Drug Discovery highlights, describes, and evaluates present clinical study utilizing microarray know-how in genomic and proteomic purposes. up-to-date and revised to mirror contemporary growth within the box, the second one variation discusses: increased omics-driven functions, together with the components
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Extra info for Applying genomic and proteomic microarray technology in drug discovery
Chem. 56(12), 1797–1803, 2010. Lillie J. Probing the genome for new drugs and targets with DNA arrays. Drug Development Res. 41: 160–172, 1997. Lobenhofer EK, Bennett L, Cable PL, Li L, Bushel PR, Afshari CA. Regulation of DNA replication fork genes by 17β-estradiol. Mol. Endocrinol. 16(6): 1215–1229, 2002. MacBeath G, Schreiber SL. Printing proteins as microarrays for high-throughput function determination. Science 289: 1760–1763, 2000. Malone JH, Oliver B. Microarrays, deep sequencing and the true measure of the transcriptome.
2001). Agilent’s SurePrint Whole Human Gene microarray slides contain 41,000 elements (135 microns each) comprising 60mer probes that are in situ printed onto a standard 1" × 3" slide. Another approach that attracted considerable attention was the introduction of the virtual (photolithographic) mask using the Digital Micromirror Device (DMD) (Texas Instruments). Singh-Gasson et al. 4). g. 4 Digital Micromirror Device (DMD). (From Singh-Gasson S, Green RD, Yue Y, et al. Maskless fabrication of light-directed oligonucleotide microarrays using a digital micromirror array.
Schroder et al. (2010) utilized dual-color labeling in proteomic profiling experiments involving a microarray of 810 antibodies against differentially expressed cancer protein targets. Dual-color labeling was found to offer greater reproducibility over that of single-color labeling. Chemical modification of proteins can lead to denaturation and aggregation. This can reduce both specificity (increased nonspecific binding) and sensitivity (decreased ligand affinity). Sandwich assay—This format works well for ELISA.
Applying genomic and proteomic microarray technology in drug discovery by Robert S. Matson