By Eberhard Nieschlag, Hermann M. Behre, Susan Nieschlag
This is often the third, completely revised version of a well known textbook that keeps to symbolize the premiere within the literature on scientific andrology. It examines intensive all facets of male reproductive overall healthiness, encompassing the fundamental body structure of male reproductive functionality and a variety of issues. all of the chapters is written through awesome specialists within the box. one of the subject matters coated are: Testicular functionality, sperm maturation and fertilization, diagnostic tactics, infertility, fundamental and secondary hypogonadism, late-onset hypogonadism, erectile disorder, genetic problems, environmental impacts, psychology and sexual drugs, testosterone treatment, assisted replica: TESE and ICSI, cryopreservation, male birth control and ethics in andrology.
This quantity will function a textbook for the newcomer to andrology, whereas supplying the skilled health professional with a important reference paintings. it's going to attract all who're taken with male reproductive health.
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Extra resources for Andrology: Male Reproductive Health and Dysfunction
In about 10% of patients with Kallmann syndrome and anosmia due to a hypoplasia of the bulbus olfactorius, mutations or deletions of the KAL1 gene on the X chromosome were detected. This gene was the first implicated in Kallmann syndrome and encodes for anosmin-1 which is produced in the bulbus and in other tissues, and which is transiently expressed as an extracellular matrix and basal membrane protein during organogenesis and interacts with heparan sulphate. Other genes implicated in GnRH neuron migration and Kallmann syndrome are those encoding the fibroblast growth factor receptor 1 (FGFR1) and its ligand fibroblast growth factor 8 (FGF8), as well as prokineticin 2 (PK2) and its receptor (PKR2) (Falardeau et al.
When expressed in millions of sperm per g/ testis in 24 h, the rat has values of 10–24, non-human primates values of 4–5 and men values of 3–7. Since earlier work also suggested that about 50% of germ cells are lost during the meiotic divisions human spermatogenesis has been considered inefficient. However, studies using contemporary stereological approaches failed to detect meiotic germ cell losses in primates including men (Zhengwei et al. 1997, 1998a, b). 8 Fig. 7 Spermatogenic efficiency index (mean ± SEM) and meiosis indices for New World monkeys (Callithrix jacchus = marmoset, n = 4), Old World monkeys (Macaca fascicularis = cynomolgus monkey, n = 5; Papio hamadryas = Hamadryas baboon, n = 6) and man (Homo sapiens, n = 9) based upon flow cytometric analyses of testicular tissue.
3). In the acrosomal phase the cell nucleus becomes further condensed and elongation of the cell continues. During condensation the majority of histones are lost and gene transcription stops. Nuclear chromatin is now extremely condensed, implying that the proteins necessary for spermiogenesis have to be transcribed before this timepoint and justifying the finding of RNA species with very long half-life and RNA binding proteins. This is the case for transition proteins and protamines. The mRNA translational control mechanisms are just being unravelled and RNA-binding proteins seem to play an important role.
Andrology: Male Reproductive Health and Dysfunction by Eberhard Nieschlag, Hermann M. Behre, Susan Nieschlag